Irsogladine maleate (JP17); Gaslon N (TN). Formula. C9H7Cl2N5. C4H4O4. Exact mass. Mol weight. Structure, Mol file KCF file DB search. View and buy high purity Irsogladine maleate from Tocris Bioscience. PDE4 inhibitor; antiulcer agent. Description. You can increase or mucus to protect the stomach, gastric mucosal blood flow better and increase the resistance to gastric acid, I will often heal.

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In the colon, no remarkable change was observed following treatment with irsogladine maleate. The numbers and sizes of polyps and their distributions in the intestine were assessed with a stereoscopic microscope. The RCs abbreviations naleate listed in the Materials and Methods section. Moreover, the levels of oxidative stress-related markers, reactive carbonyl species, in the livers of Min mice were clearly decreased following the administration of irsogladine maleate.

In addition, another report described the suppressive effects of irsogladine maleate on diethylnitrosamine DEN -initiated and phenobarbital-promoted hepatocarcinogenesis in male F rats [ 11 ]. Preparing Stock Solutions The following data is based on the product molecular weight Citations for Irsogladine maleate Citations are publications that use Tocris products. The regulation of AP-1 activity by mitogen-activated protein malezte.

The administration of 5 and 50 ppm irsogladine maleate to Min mice for 8 weeks did not affect body weight, food intake or clinical signs throughout the experimental period.

In irsogladind, there were no observed changes in organ weights that might have been attributable to toxicity. Prevention and intervention trials for colorectal cancer. Concentration 2 femtomolar picomolar nanomolar micromolar millimolar molar.


Activates gap-junctional intercellular communication improving gastric mucosal barrier function. Thus, we aimed to identify an ideal gastric mucosal protectant with anti-oxidative stress and anti-intestinal tumorigenesis potential.

Estimates of worldwide burden of cancer in Similar results obtained in HCT cells support the reliability of our results. The system was operated at a constant flow rate of 0. Privacy and Cookie Policy Site Map. Based on the reduced levels of reactive carbonyl species RCs in Min mice treated with irsogladine maleate, the mechanisms underlying the suppressive effect of the drug on intestinal tumorigenesis are also discussed.

We calculated the dose of 5 and 50 ppm that corresponds to a human dose. Journal List Oncotarget v. In this study, we only aimed to identify gastric mucosal protectants that suppress intestinal tumorigenesis in a mouse model, and left for future experiments whether the combined treatment of aspirin and gastric mucosal protectants inhibits intestinal carcinogenesis while suppressing the side-effects of aspirin.

Caco-2 cells, a human colon adenocarcinoma cell line, were purchased from Sumitomo Dainippon Pharma Co. There are currently no reviews for this product. The intestinal tract was removed and separated into the small intestine, cecum and colon.

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Irsogladine maleate | C13H11Cl2N5O4 – PubChem

The data suggested the effects of 5 ppm irsogladine maleate plateaus, and higher doses did not efficiently decrease polyp numbers. Krsogladine comparative RCs profiles of liver samples from 5 A.

Structure, regulation and function of NF-kappa B. Find out more about irsogladije libraries available from Tocris. The data using 0. As aspirin is a nonselective and irreversible cyclooxygenase COX -inhibitor, aspirin inhibits platelet aggregation and can reduce thrombosis. Mass picograms nanograms micrograms milligrams grams kilograms. Acknowledgments We benefitted from the technical support of Mrs. Angel P, Karin M. Cell culture Caco-2 cells, a human colon adenocarcinoma cell line, were purchased from Sumitomo Dainippon Pharma Co.


The linear gradient conditions were as follows: To assess the specificity of each primer set, amplicons generated from the PCR reactions were analyzed for melting curves. For safety purposes in the long-term use of cancer chemopreventive agents, weak inhibitors may be advantageous.

Irsogladine maleate

The preventive effects of low-dose enteric-coated aspirin tablets on the development of colorectal tumours in Asian patients: Accumulation of lipid peroxidation-derived DNA lesions: Mleate 1 nanoliter microliter milliliter liter. This study demonstrated that irsogladine maleate suppresses intestinal polyp formation in Min mice partly through the NF-jB signaling pathway, thus reducing oxidative stress. An efficient conversion of carboxylic acids to one-carbon degraded aldehydes via iraogladine acids.

Concentration femtomolar picomolar nanomolar micromolar millimolar molar. Low-dose aspirin for primary prevention of cardiovascular events in Japanese patients 60 years or older with atherosclerotic risk factors: Furthermore, the chemopreventive property of irsogladine maleate was examined in a Min mouse model of familial adenomatous polyposis.

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Alpha-oxidation of fatty acids in higher plants. Akakabe Y, Nyuugaku T.

Barnes PJ, Karin M. Please let us know. We hypothesized that combining aspirin administration with a gastric mucosal protectant would reduce the risk of gastrointestinal bleeding. Concomitant suppression of hyperlipidemia and intestinal polyp formation in Apc-deficient mice by peroxisome proliferator-activated receptor ligands. Jpn J Cancer Res.