Controlled release matrix tablets with HPMC KLV, HPMC K4M, HPMC K15M, and HPMC KM were formulated by wet (non-aqueous) granulation method. Surface plots of log viscosity with temperature (°C) and HPMC concentration (%, w/w) for HPMC a K LV, b K4M, c K15M and d KM. Download/Embed scientific diagram | Swelling index of HPMC K4M at different concentrations from publication: Influence of different grades and concentrations .

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Granule and tablet formulae study by hhpmc component analysis. It is likely that the variation in the particle shapes of the different HPMC grades affected particle-particle interactions to a certain extent.

Hypromellose – Wikipedia

Particle size and size distribution of HPMC played important roles in the viscosity of melt suspensions with smaller particles leading to a greater viscosity than larger particles. In all polymer formulations, the degradation rate constant increased with increase in the polymer proportion.

The reason for the decrease in the release with increase in the polymer proportion might be explained as follows for water-soluble drug isoniazid.

An understanding of the rheological behaviour of polymer melt suspensions is crucial in pharmaceutical manufacturing, especially when processed by spray congealing or melt extruding. Factors affecting mechanism and kinetics of drug release from matrix-based oral controlled drug delivery systems. Multiparticulate oral drug delivery. Size distribution curves were plotted, and the median particle size, d 50was obtained. The in vitro release profiles were studied as per the specifications enlisted in previous sections and compared with their respective initial release profiles.

Ophthal Plast Reconstr Surg. Comparison of single pot and multiphase high shear wet granulation processes related to excipient composition.

Each sample was transferred to the rheometer plate and excess removed with a spatula. Hypromellose solutions were patented as a semisynthetic substitute for tear-film.

Molar substitution is the average level of upmc substitution on the cellulose chain. A higher concentration of solids in the polymer melt retarded the flow of the melt, resulting in higher viscosity.

The low standard deviation values for all physical properties showed that there was excellent batch-to-batch reproducibility and absence of significant batch-to-batch variations. Thus, the present study aimed at the design of isoniazid CR formulations by using relatively simple manufacturing technology which can be easily adopted in industrial units on a commercial scale. The shear stress was set at 6. Thus, from the present studies, it was observed that the HPMC formulations could provide both the advantages initial higher release followed by controlled release in a single controlled release tablet formulation.


Benecel™ Hydroxypropylmethylcellulose (HPMC) K4M

Generally, the lower viscosity grades permitted a higher load of HPMC before becoming too viscous compared to higher viscosity grades. Published online Nov 6. However, a detailed comparison of the viscosities at each and every temperature and concentration between the various grades of adjuvants in the formulation will be tedious and time-consuming. The following variations in tablet formulae were done and their effect on in vitro release rate, release mechanism Fickian or non-Fickianand nature of release order of release was studied.

Acknowledgments The authors declare no conflict of interest.

Controlled Release Hydrophilic Matrix Tablet Formulations of Isoniazid: Design and In Vitro Studies

Eur J Pharm Biopharm. These results indicated that the IPA granulation method is an acceptable method for preparing good quality matrix tablets of isoniazid.

This enabled the selection of an appropriate grade and concentration of HPMC to achieve the desired viscosity in the pharmaceutical process. Hypromellose augmentation therefore results in extended lubricant time presence on the cornea, which theoretically results in decreased eye irritation, especially in dry climates, home, or work environments.

The particles were mounted on aluminium studs using conductive carbon tapes and examined at 1. The f 2 factor value was observed to be Surface plots showed that concentration of HPMC had a greater effect on the viscosity compared to temperature. Size determinations were triplicated and the results averaged. bpmc

There are several reports in the literature which substantiated the need for the controlled release formulations of isoniazid 1214 — Polymer rheology plays a crucial role in polymer processing and polymer manufacturing.

At early times, drug close to matrix surface might be released before the surrounding polymer reached the polymer disentanglement concentration the concentration of the polymer in a fully hydrated state at which there are no polymer—polymer interactions because the diffusion coefficients for drug molecules were k4j than the polymer.

Various formulation factors influence the drug release form HPMC matrices, viz. This product is widely used in food applications such as batters, breadings, extruded hmc fried foods, bakery fillings and toppings, meat hmc meat substitutes, soups, sauces, ice cream, and more. The reason for initial higher release and decrease in the rate of isoniazid with time can be explained as follows.


Therefore, the l4m of viscosity hpmf PEG melt suspension is more readily achieved by modifying the amount of solids rather than regulating the temperature of the process. Post-application, celluloid attributes of good water solubility reportedly aid in visual clarity. Formulations in the low viscosity cluster were found to be sprayable. Since there are maximum three possible sites of substitution with each cellulose molecule, this average value is a real number between 0 and 3.


Celluloses such as homc methylcellulose HPMC are used in many pharmaceutical applications as sustained release agents, tablet binders, suspending agents, thickening agents, viscosity-increasing agents and film-coating One of such method is principal component analysis PCA which allows the visualisation of the most important information contained in the data set Significant difference in the release profiles of the tablets compressed to the hardness of 4.

Therefore, the use of better and faster analytical method, such as PCA, can be suitable for k4 the viscosity profiles of ternary melt suspensions. The aim of the present investigation was to develop oral controlled release matrix tablet formulations of isoniazid using hydroxypropyl methylcellulose HPMC as a hydrophilic release retardant polymer and to study the influence of various formulation factors hpmx proportion of the polymer, polymer viscosity grade, compression force, and release media on the in vitro release characteristics of the hpmmc.

However, degree of substitution is often expressed in percentages. Abstract The aim of the present investigation was to develop oral controlled release matrix tablet formulations of isoniazid using hydroxypropyl methylcellulose HPMC as a hydrophilic release retardant polymer and to study the influence of various formulation factors like proportion of the polymer, polymer viscosity grade, compression force, and release media on the in vitro release characteristics of hpkc drug.

Especially, the high viscosity polymers would take longer time to form a gel layer. The formulations within each group in line plot Fig. Although polymers have been studied over the years, polymer rheology is a difficult subject to comprehend 1. Retrieved from ” https: The two axes in the scores plot represent the principal components PCswhich are variables used to differentiate the data.

Hppmc, the drug has good solubility in the release medium, and hence, the drug present on the surface might have been released quickly because of the presence of the more pores in the matrix structure.