Granulosis rubra nasi is a rare condition characterised by hyperhidrosis of the nose. Granulosis Rubra Nasi (GRN) is a rare disorder of the eccrine glands. It is clinically characterized by hyperhidrosis of the central part of the face. Granulosis rubra nasi is a rare familial disease of children, occurring on the nose, cheeks, and chin, characterized by diffuse redness, persistent excessive.

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Andrew’s Disease of the Skin. This is a case report of a year-old male patient who presented with excessive sweating over the nose. Granulosis rubra nasi in a mother and daughter.

To receive news and publication updates for Case Reports in Dermatological Medicine, enter your email address in the box below. However, telangiectatic blood vessels and some erythema were still persisting. This condition of the skin appendages article is a stub. Granulosis rubra nasi is a rare disorder of the eccrine glands first described by Jadassohn in Papillary dermis shows dilated capillaries naai extravasation of hemosiderin Figure 2.

Granulosis rubra nasi: a rare condition treated successfully with topical tacrolimus

It yranulosis commonly seen in childhood but it can present in adults. View at Google Scholar O. He was otherwise well and there was no relevant family history. Notice and credit must be given to the PCDS or other named contributor. There are no complications associated with the condition and the disease has excellent prognosis with self-resolution. Some authors have suggested a defect in vasomotor and secretory functions of the nose.


The differential diagnosis includes rosacea and perioral dermatitis. Web Design – Mode Ten Designs. The patient has been treated with topical tacrolimus 0.

Granulosis rubra nasi GRN is an inflammatory condition involving eccrine sweat glands of central face and clinically presents as erythema, hyperhidrosis, papules, pustules and vesicles over central face. This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.

It is an inflammatory dermatosis involving eccrine sweat glands of central face involving nose, cheeks, or chin, representing a unique sweat retention form [ 2 ]. Paronychia Acute Chronic Chevron nail Congenital onychodysplasia of the index rubrq Green nails Half and half nails Hangnail Hapalonychia Hook nail Ingrown nail Lichen planus of the nails Longitudinal erythronychia Malalignment of the nail plate Median nail dystrophy Mees’ lines Melanonychia Muehrcke’s lines Nail—patella syndrome Onychoatrophy Onycholysis Onychomadesis Onychomatricoma Onychomycosis Onychophosis Onychoptosis granulossis Onychorrhexis Onychoschizia Platonychia Pincer nails Plummer’s nail Psoriatic nails Pterygium inversum unguis Pterygium unguis Purpura of the nail bed Racquet nail Red lunulae Shell nail syndrome Splinter hemorrhage Spotted lunulae Staining rybra the nail plate Stippled nails Subungual hematoma Terry’s nails Twenty-nail dystrophy.

Ueber die Beziehungen des Hidrocystoms zur Granulosis rubra nasi.

Granulosis rubra nasi – Wikipedia

Treatment of granulosis rubra nasi with botulinum toxin type A. It runs a chronic course and resolves at puberty without any sequale. It is rare with autosomal dominant or autosomal recessive pattern of inheritance. After another three months of follow up, patient had not developed any new lesions and had not experienced any significant side effects of Tacrolimus. Small beads of sweat can be seen at the tip of the nose. Website author — Dr Tim Cunliffe read more. Subscribe to Table of Contents Alerts.


Eccrine hidrocystoma also shows dilatation of sweat glands with solitary or multiple cysts lined by a double layer of cuboidal cells on histology, but dilatation of dermal vessels and perivascular mononuclear infiltrate is not seen [ 410 ].

All named individuals and organisations maintain copyright for the relevant images. GRN is a rare disorder.

Granulosis rubra nasi

Physical examination of the nose revealed erythema and multiple telangiectatic vesicles. Footnotes Source of Support: Support Center Support Center. View at Google Scholar E. Granulosjs corticosteroids help by reducing the inflammatory infiltrate around sweat glands.

Rashid, Granulosis rubra nasihttp: There was history of summer aggravation; however, she was never lesions free, even during winter months. Please click on images to enlarge or download. Ingrown nail Anonychia ungrouped: We are not in a position to comment on the response of tacrolimus in earlier stages of disease process, rugra hyperhidrosis is prominent as we got the patient in a very late stage.