Eurand’s Diffucaps® technology enables the development of once-daily controlled-release (CR) capsules or patient-friendly orally disintegrating tablet ( ODT). Download scientific diagram | ORBEXA ® Technology 3) DIFFUCAPS ® Technology: Diffucaps is a multiparticulate bead system comprised of multiple layers of. DIFFUCAPS ® technology 4) DIFFUTAB ® Technology: Diffutab technology enables customized release profiles and region-specific delivery. Diffutab.

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Journal List Biomatter v. As the drug in a nanosuspension is released, the drug nano particles are dispersed, and aggregation is prevented. Lipid technology—a promising drug delivery system for poorly water soluble drugs. Although several milestones have been reached in this respect, there are still some unexplored facets of pulsatile drug delivery that can open new vistas through better engineering of the same.

Floating or pulsatile drug delivery systems based on coated effervescent cores. Now-a-days, the emphasis of pharmaceutical researchers is turned towards the development of more efficacious drug delivery systems with already existing molecule. OROS delivery systems were adopted for poorly water soluble drugs.

Diffucps people function best in the morning while others have their peak in the noon or evening. Asian J Pharm ; The Eurand Minitabs can be formulated as matrix tablets prior to further coating.

9. Pulsatile Drug Delivery System: Method and Technology Review | Insight Medical Publishing

Int J Pharm Res Devel. Eurand applied this technology to both soluble and insoluble products. Increasing the strength of the ultrasound resulted in a proportional increase in the amount of 5- fluorouracil released1, 2,3, Patel and Patel developed a modified Pulsincap device containing diclofenac sodium to target the drug in the colon.

Available in both mg and mg tablets, Techology is designed for oral dosing at bedtime.

This in turn acts as a pump to push more amount of the active solute out of the matrix 1, 2,3, In these systems, the drug is released after stimulation by any biological factor, like temperature or any other chemical stimuli. Implantable, polymeric systems for modulated drug delivery. Microchips as controlled drug-delivery devices. A drug core granulated or layered onto a neutral surface is created, followed by the application of one tecbnology more rate-controlling, functional polymer membranes.


The drug can be combined in two ways, one with the neutral core second incorporated into the coating process Open in a separate window. Timing drug availability with therapeutic need.

Diffucaps technology in its simplistic form involves the preparation of 12, 18, 20, However, there are some problems that limit the further applications of the system, such as the selection of suitable excipients and the pharmacotechnical properties of 3DP products. Thermosensitive hydrogels have been investigated as possible drug delivery carriers for stimuli-responsive drug delivery. AMRIX is available in two dose-proportional strengths, 15 and 30 mg capsules.

The controlled-onset delivery system results in a maximum plasma concentration C max of verapamil in the morning hours. Shorter duration oscillations are termed as Ultradian Rhythms more diffucapss one cycle viffucaps 24 h.

9. Pulsatile Drug Delivery System: Method and Technology Review

Gastro retentive drug delivery system is a suggestion to prolong gastric residence time, thereby targeting site-specific drug release in upper gastrointestinal GI tract. These systems depend on the disintegration of the diffuczps layer for the release of a drug. These pellet-filled capsules provide for extended release of the drug in the gastrointestinal tract.

In case of techmology diseases, BP is at its lowest during the sleep cycle and rises steeply during the early morning period. The whole unit is coated with an enteric polymer to avoid the problem of variable gastric emptying. Developing a modified pulsincap system. In such systems the drug release is controlled by diffucas dissolution or erosion of the outer coat which is applied on the core containing drug Tecgnology. These rhythms allow organism to anticipate and prepare for precise and regular environment changes.


This nighttime release formulation is especially suited to the treatment of early morning stiffness, which is associated with rheumatoid arthritis caused by the marked release of inflammatory cytokines, including interleukin-6 IL-6 digfucaps the early hours of the morning. The sub-systems, multi-particulate systems e.

The oral controlled-release systems show a typical pattern of drug release in which the drug concentration is maintained diffucasp the therapeutic window for a prolonged period of time, thereby ensuring sustained therapeutic action. They provide constant drug levels at the site of action and prevent the peak-valley fluctuations.

In sleep wake cycle, an animal will settle into a 24 hour cycle activity and diffucsps even if deprived of light. Hence, there is a time lag before the drug can be released corresponding to the time required for critical molecular weight to be reached.

Internally stimuli induced system 2. An osmotic pressure can be built up within the interior of the particle when water allows entering under the right circumstances. Chronic, programmed polypeptide delivery from an implanted, multireservoir microchip device.

Three-dimensional printing in pharmaceutics: Such a release pattern is known as pulsatile release. Traditionally, drugs are released in an immediate or extended manner. Stimuli-based drug delivery systems release the drug in response to stimuli that are induced by the biological environment. The push layer contains among other things, an osmotic agent and water swellable polymers.

The length of the plug and its point of insertion into the capsule controlled the lag time.