Download Citation on ResearchGate | Cancer de la ampolla de Vater | The authors report the results of studies on five patients -3 males and 2 females- with . Periampullary tumors are neoplasms that arise in the vicinity of the ampulla of Vater. Neoplasms that arise in this site can originate from the. Metastasis of breast cancer to major duodenal papilla Palabras clave: Ampolla de Vater; Neoplasias de la mama; Ictericia (fuente: DeCS BIREME).

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The role of radiotherapy in the management of extrahepatic bile duct vancer A papillotomy was performed and a 10 French x 9 cm plastic stent was placed in the common bile duct.

Only a few studies have focused on this specific group of tumors and the available case series are generally small. Demographics, histological features, stage, treatment received and outcome of 20 cases of ampullary carcinoma.


In this report we present a vzter of biliary obstruction due to metastatic breast cancer ve the major duodenal papilla. A multicenter, international, open-label, randomized controlled phase III trial of adjuvant chemotherapy versus observation in patients with adenocarcinoma of the ampulla of vater.

Huibregtse KTytgat GN. Tis Carcinoma in situ. Patients were divided in 2 subgroups: Am J Surg Pathol. Ampullary carcinoma, Chemotherapy, Radiotherapy, Biliary tract cancer. Gemcitabine-based adjuvant chemotherapy improves survival after aggressive surgery for hilar cholangiocarcinoma. The cystic duct amplla the gallbladder and joins with the common hepatic duct to form the common bile duct.


Report of a case and a cancer de ampolla de vater of the literature. Table 3 Studies on adjuvant chemo-radiotherapy. Demographics, histological features, aampolla, treatment received and outcome of 20 cases of ampullary carcinoma.

Prognostic factors for ampullary adenocarcinomas: Since EGFR overexpression strongly correlates with tumor progression in biliary cancer[ 72 ], the use of anti EGFR seems to be a promising therapeutic option. Most ampullary tumors are adenocarcinomas, but are occasionally papillary, adenosquamous or mucinous.

Treatment options for advanced or unresectable stages vter discussed below. A gemcitabine plus capecitabine schedule was tested in 45 patients with advanced biliary cancer and no prior chemotherapy[ 67 ].

Although metastases of breast carcinomas are infrequent to the gastrointestinal tract, neoplasms of the juxtapapillary region should amplola suspected, especially at an early stage, since curative resection can be offered.

Conversely, the survival rate of ampullary cancer with pancreatobiliary differentiation appears to be comparable to that of pancreatic cancer[ 2627 ].

In another randomized study, patients with pancreatic or periampullary cancer received either adjuvant intra-arterial chemotherapy mitoxantrone, 5-FU, leucovorin, and cisplatinum combined with radiotherapy or no adjuvant treatment[ 41 ]. National Center for Biotechnology InformationU. Time to progression; LD: Carcinoma of the ampulla of vater.

Similar distribution of demographic characteristics and stage between ampullary and other biliary tract cancers was observed.

Tumors of ampulla of Vater: A case series and review of chemotherapy options

Role of adjuvant chemoradiotherapy for ampulla of Vater cancer. Peripancreatic lymph nodes are included with the resection.

Images hosted on other servers: Unfortunately, the benefit achieved following postoperative chemo-radiation in patients with pancreatic, periampullary and ampullary cancer observed in some studies[ 38404245 ] was not confirmed in others, including two randomized studies[ 37394143 ].


The efficacy of a gemcitabine-based as compared to a 5FU-based adjuvant treatment was also emphasized by another trial, in which chemotherapy for 3 wk prior and for 12 wk after CCRT was administered[ 50 ]. The Ampulla of Vater is a flasklike cavity into which both the common bile and pancreatic ducts open. T0 No evidence of primary tumor. Experience with consecutive tumors of the duodenum, ampulla, head of the pancreas, and distal common bile duct. The laboratory evaluation revealed bilirubin totals 7.

Need a Curbside Consult? Impact of postoperative irradiation after non-curative resection of hilar biliary cancer. World J Gastrointest Oncol. Tumor of the ampulla of Vater: Phase II study of capecitabine and oxaliplatin for advanced adenocarcinoma of the small bowel and ampulla of Vater. Recurrence rate is high in this population; therefore, surveillance endoscopy is indicated.

Malignant neoplasms affecting the major duodenal ampoolla are rare, and the adenocarcinoma is the histological type in almost all cases, but occasionally other histological types such as carcinoid tumors, squamous cell and mucinous carcinomas can be found 4. Tumor staging with laparoscopy and laparoscopic ultrasonography.

Registry data collection variables. Intestinal ampullary adenocarcinomas originate from the intestinal epithelium overlying the vwter whereas pancreaticobiliary ampullary carcinomas originate from the epithelium of the distal common bile duct and distal pancreatic duct.

Smeenk et al[ 39 ]