PDF | The present study aims to evaluate the therapeutic properties of the medicinal plants (Vitex negundo, Aegle marmelos and Boswellia serrata) for their . Abstract To evaluate the anti-inflammatory activity of Vitex negundo (VN) leaf extract and its mechanism of action in experimental animals. Carrageenin induced. Abstract. The present study was undertaken to assess the anti-inflammatory effect of ethanolic extract of Vitex negundo roots in rats.

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Sivarajan VV, Balachandran I. Indian Council of Medical Research India 2: International Journal of Pharmacology, 2: Carrageenan-induced paw edema being an in-vivo investigational model for acute inflammation which been extensively used to determine the anti-inflammatory effect of new investigational agents.

The present study therefore, intends to investigate the aftivity activity of hydroalcoholic leaves extracts of polyhedral formulation of Murraya Koenigii and Vitex Negundo on carrageenan induced inflammation in experimental animal models, in order to confirm the medicinal properties of the plant. An infusion of the toasted leaves in used to stop vomiting [ 6 ]. Moreover very few reports Dharmasiri et al. Effects of Luffa echinata on lipid peroxidation and free Radical scavenging Activity.

Although, leaves of VN have been investigated for its anti-inflammatory activity in past Telang et al. The tubes were then centrifuged at rpm for 10 min and cooled.

Antioxidant and Antiinflammatory Activity of Vitex negundo

Similarly, fresh leaves of VN have been suggested to possess anti-inflammatory and pain suppressing activities possibly mediated via PG synthesis inhibition, antihistamine, membrane stabilising and antioxidant activities Dharmasiri et al. Kundnani College of Pharmacy.

On the contrary, Sahni et al. The paw edema volume was invlammatory with the help of plethysmometer at zero hour. Animals were observed for clinical signs and mortality, continuously for first 2 h. The reduction in the volume displacement of hind foot in comparison to control was taken as anti-inflammatory effect. Khare CP Indian medicinal plants an illustrated pf.


Medicinal uses and biological activities of Vitex negundo. It is well established that oxytocin induced uterine contractions are partly mediated through prostaglandins Rall, Natural phenolic in the prevention of UV-induced skin damage: The basic literature survey exposed that Vitex negundo hasantioxidant, antiulcer and anti-nociceptive activity and Murraya koenigii possessing anthelmintic, analgesic, cooling activity, but not many scientific studies have been carried out to reveal and collaborate the anti-inflammatory activity of Vitex negundo and Murraya koenigii leaves.

The effects were compared with phenylbutazone mg kg -1 orally in carrageenin induced hind paw edema method and ibuprofen mg kg Murraya koenigii; Vitex negundo ; Anti-inflammatory; Hydroalcoholic extract. The easy availability of this plant, coupled with its reported usefulness in arthritic disorders prompted us to further explore its antiinflammatory and antioxidant activity.

The animals were fasted overnight before the experiment. Anti-inflammatory and analgesic activities of mature fresh leaves of Vitex negundo. Five groups of 6 mice each were administered with aqueous extract at 1. Therefore, reduction of oxidative stress by anti-lipoperoxidative activity might possibly vitdx the mechanism of anti-inflammatory action of VN in model of sub-acute inflammation.

Antioxidant and Antiinflammatory Activity of Vitex negundo.

Studies on analgesic and anti-inflammatory activities of Vitex negundo Linn. The first phase is due to the release of histamine or serotonin, and the second phase is caused by the release of bradykinin, protease, prostaglandin, and lysosome.

Pharmacological Experiment on Isolated Preparations. This is because of the adverse effects associated with synthetic drugs. Due to increase in frequency of intake of synthetic drug and their side effect, there is need to focus on herbal drug having fewer side effect.

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For mechanism of anti-inflammatory activity: In cotton pellet granuloma test VN extract in graded dosesand mg kg The finding of present study strengthens the finding of Dharmasiri et al. Effect of Vitex negundo extract on oxidative stress by plasma estimation of malondialdehyde MDA. Gallic acid and 1,1-diphenylpicrylhydrazyl was procured from Sigma Aldrich Co.

The clearance for the use of animals for experimental purpose was obtained from institutional ethical committee constituted for the purpose at M. Abstract Reactive oxygen species are implicated in various inflammatory disorders. Screening of anti-inflammatory activity of certain indigenous drugs on carrageenin induced hind paw oedema in rats. Vitex negundo is mentioned in Ayurveda as useful in treating arthritic disorders.

Ayurvedic drugs and their plant sources. The results strongly suggest that radical quenching may be one of the mechanisms responsible for its antiinflammatory activity.

For mechanism of action: Effects of test drugs on oxytocin induced rat uterus contractions were compared to original response of oxytocin in term of height in cms, which served as control. The present investigations have demonstrated a strong correlation between anti-inflammatory and antioxidant activities of V.

Their bioactivity screening and evaluation. Ati phenolics, particularly polyphenols exhibit a wide variety of beneficial activities in acttivity including antiviral, antibacterial, immune stimulating, antiallergic, antihypertensive, antiischemic, antiarrythmic, antithrombotic, hypocholesteromic, hepatoprotective, antiinflammatory, anticarcinogenic This article has been cited by other articles in PMC.

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