HYPERVARIABLE MINISATELLITE REGIONS IN HUMAN DNA PDF

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The human genome contains many dispersed tandem-repetitive ‘minisatellite’ regions detected via a shared 10–base pair ‘core’ sequence similar to the. Genetic analysis is now simplified by the availability of probes for hypervariable regions of human DNA showing multiallelic variation and correspondingly. A minisatellite is a tract of repetitive DNA in which certain DNA motifs are typically repeated times. Minisatellites occur at more than 1, locations in the human genome and In humans, 90% of minisatellites are found at the sub- telomeric region of “Hypervariable ‘minisatellite’ regions in human DNA”. Nature.

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Hypervariable ‘minisatellite’ regions in human DNA.

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If you originally registered with a username please munisatellite that to sign in. Add comment Close comment form modal. We present DNA sequences flanking cloned hypervariable human minisatellites.

Minisatellites also constitute the chromosomal telomeres, which hyprrvariable the ends of a chromosome from deterioration or from fusion with neighbouring chromosomes.

Sequences flanking the repeat arrays of human minlsatellites: Citing articles via Web of Science This article needs attention from an expert in Genetics.

Repeat turnover therefore appears to be controlled by recombinational activity in DNA that flanks the repeat array and results in a polarity of mutation. Oxford University Press is a department of the University of Oxford. Please help us clarify the article. Minisatellites are prominent in the centromeres and telomeres of chromosomes, the latter protecting the chromosomes from damage.

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Hypervariable ‘minisatellite’ regions in human DNA

Dynamic evolution of megasatellites in yeasts. Thank you for submitting a comment on this article. Close mobile search navigation Article navigation. This regilns is also available for rental through DeepDyve. Please help improve it or discuss these issues on the talk page.

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These findings have suggested that minisatellites most probably evolved as bystanders of localized meiotic recombination hypervarable in the human genome. Retrieved from ” https: Minisatellite variant repeat mapping by PCR MVR-PCR has been extensively used to chart the interspersion patterns of mibisatellite repeats along the array, which provides details on the structure of the alleles before and after mutation. By using this site, you agree to the Terms of Use and Privacy Policy.

These variant repeats are tandemly intermingled. Jeffreys; Sequences flanking the repeat arrays of human minlsatellites: This article has multiple issues. For the size class of orbiting spacecraft, see miniaturized satellite.

The first human minisatellite was discovered in by A. Studies have shown [ citation needed ] that the evolutionary fate of minisatellites tends towards an equilibrium distribution in the size of alleles, until mutations in the flanking DNA affect the recombinational activity of a minisatellite by suppressing DNA instability.

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Most users should sign in with their email address. It has been proposed that minisatellite sequences encourage chromosomes to swap DNA. Don’t have an account? Emery’s Elements of Medical Genetics, 12th. Minisatellites were subsequently also used for genetic markers in linkage analysis and population studies, but were soon replaced by microsatellite profiling in the s.

More on this topic A novel tRNA variable number tandem repeat at human chromosome 1q When shorter 10—bp tandem repeats were later identified, they came to be known as minisatellites.

Hypervariable ‘minisatellite’ regions in human DNA.

We present our own findings concerning this element, in particular that those examples studied do not show significant evolutionary conservation, despite suggestions that the element may have a cis-acting function. Views Read Edit View history.

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