PDF | The present study aims to evaluate the therapeutic properties of the medicinal plants (Vitex negundo, Aegle marmelos and Boswellia serrata) for their . Abstract To evaluate the anti-inflammatory activity of Vitex negundo (VN) leaf extract and its mechanism of action in experimental animals. Carrageenin induced. Abstract. The present study was undertaken to assess the anti-inflammatory effect of ethanolic extract of Vitex negundo roots in rats.

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Stabilization of the Prussian blue colour in the determination of polyphenols. Curcumin was used as positive control. Indian Council of Medical Research India 2: The tissue damage then provokes inflammatory response by the production of mediators and chemotactic factors 4. The tubes were then centrifuged at rpm for 10 min and cooled. It is concluded that hydroalcoholic leaves extract of Vitex negundo and Murraya koenigii can negnudo protection against carrageenan induced paw edema in rats.

Inhibition of prostaglandin synthesis as a mechanism of action acivity aspirin-like drugs. We also extend our sincere thanks to Dr. Ayurvedic drugs and their plant sources.

Two methods were employed to evaluate the anti-inflammatory activity as well as potentiation effect of phenylbutazone and Ibuprofen anti-inflammatory action by VN. Please leave a message, we will get back you shortly.


Oct 06, Abstract Vitex negundo and Murraya koenigii are popular Indian herbs inflammatoru are used for various clinical disorders.

Antioxidant and Antiinflammatory Activity of Vitex negundo.

The phenolics, particularly polyphenols exhibit a wide variety of beneficial activities in mammals including antiviral, antibacterial, immune stimulating, antiallergic, antihypertensive, antiischemic, antiarrythmic, antithrombotic, hypocholesteromic, hepatoprotective, antiinflammatory, og A positive lipid peroxidation inhibitory activity of the extract of V.

The plant was collected from local area of Sevagram in the month of June, The animals were divided into five groups with each group consisting of ten animals.

The vitamin-C and carotene content ati several herbs and flowers used in ayurvedic system of medicine. Sivarajan VV, Balachandran I. Absorbance of the resulting pink chromogen was recorded at nm.

Antioxidant and Antiinflammatory Activity of Vitex negundo

The present investigations have demonstrated a strong correlation between anti-inflammatory and antioxidant activities of V. Robbins, Pathologic Basis of Disease. More over anti-ulcer activity of VN reported by Sahni et al. Oxygen toxicity and antioxidants: Author information Article notes Copyright and License information Disclaimer.

Mice were fasted overnight before the day of experiment and the liver was promptly excised after sacrificing the mice. The same procedure was repeated at 30 min 1, 2, 3 h. Vitex negundo VN Linn verbenaceaea large aromatic shrub with typical five foliolate leave pattern, found throughout the greater part of India at warmer zones and ascending to an altitude of m in outer, Western Himalayas. Herbal drugs play an important role in health care programs especially in developing countries.


Carrageenin induced hind paw edema and cotton pellet granuloma test in albino rats were employed to study the anti-inflammatory activity of Vitex negundo VN leaf extract.

The prostaglandins are known to play important role in genesis of sign and symptoms of acute inflammation Mocada et al.

Dose selection of test drug was based vvitex previously reported studies Telang et al. This method inglammatory based on reduction in absorbance of a methanol solution of coloured free radical, 1,1-diphynylpicrylhydrazyl 7.

The difference in wet and dry weights of granuloma from control group to that of treated group indicates the anti-inflammatory activity. CDepartment of Biochemistry, for allowing us to perform bio-chemical investigation in the department. For mechanism of action: It has been claimed to possess many medicinal properties Tandon,